DOMINICAN REPUBLIC

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REPUBLICA DOMINICANA



Dominican Republic is the second largest and most diverse Caribbean country, situated just two hours south of Miami, less than four hours from New York and eight hours from most European cities. Known for our warm and hospitable people, Dominican Republic is a destination like no other, featuring astounding nature, intriguing history and rich culture.

Surrounded by the Atlantic Ocean on the north and the Caribbean Sea on the south, our lush tropical island paradise boasts nearly 1,000 miles (1,609 km) of coastline, 250 miles (402 km) of the world’s top beaches, magnificent resorts and hotels, and a variety of sports, recreation and entertainment options. Here you can dance to the pulse pounding thrill of the merengue, renew in our luxurious and diverse accommodations, explore ancient relics of centuries past, delight in delicious Dominican gastronomy or enjoy ecotourism adventures in our magnificent national parks, mountain ranges, rivers and beaches.

Discovered in 1492 by Christopher Columbus, the country overflows with fascinating history, museums and exciting cultural experiences like music, art and festivals, plus uniquely Dominican specialties such as cigars, rum, chocolate, coffee, merengue, amber and larimar.

LOCATION/GEOGRAPHY

The Dominican Republic occupies the eastern two-thirds of the island of Hispaniola, which it shares with the Republic of Haiti. The country is the second largest in the Caribbean region, with a surface area of 18,533 square miles (48,442 square kilometers). Located in the heart of the Caribbean, the Dominican Republic is surrounded by the Atlantic Ocean to the north and to the south by the Caribbean Sea.

POPULATION
The population of the Dominican Republic is 9,378,819 (2010 Census).

TIME ZONE
Local time is GMT -4. It is an hour ahead of Atlantic Standard Time in the United States in the winter. Unlike the United States and Europe, the Dominican Republic does not observe daylight saving time.

CAPITAL CITY
The capital of the Dominican Republic is Santo Domingo, the oldest city in the New World. Greater Santo Domingo has a population of around three million people.

GOVERNMENT
The Dominican Republic is a representative democracy. There are three branches of government: Executive, Legislative and Judicial. Every four years the country elects its president, vice president, legislators and city government officials. President Danilo Medina and Vice President Margarita Cedeño were elected for a four-year term that began on 16 August 2012 and ends on 16 August 2016. The Constitution does not allow for consecutive re-election

LANGUAGE
Spanish is the official language of the Dominican Republic. However, you’ll be surprised how many hotel and tourist destination employees speak English, French, German and Italian. If you decide to venture out of the tourist areas, it is helpful to learn some basic phrases in Spanish.

CURRENCY
The Dominican Peso (RD$) is the official currency of the Dominican Republic. You can find the peso exchange rate for several international currencies at www.bancentral.gov.do/tasas_cambio/TMC4001.PDF
Major credit cards are accepted at most tourist locations, but it is best to check in advance at small hotels, restaurants and shops.
ATMs are located in almost all of the Dominican Republic’s cities, as well as at most resorts. Large supermarkets have ATMs that are open until late.

CLIMATE
The Dominican Republic enjoys a tropical climate all year round, with average temperatures ranging from 66° to 93° F (19° to 34° C). The coldest season is between November and April, and the hottest season is between May and October. August is the hottest month.

TOURISM STATISTICS
4,064,754 non-resident foreigners flew to the Dominican Republic in 2013. A further 625,016 non-resident Dominicans also chose to visit in 2013. The Dominican Republic received 26.81% of the record number of 15,663,409 million visitors to the Caribbean region in 2013.

Most air arrivals landed at the Punta Cana airport, 63.6% of all air traffic. Santo Domingo was the second destination of arrivals with 19.7%, followed by Puerto Plata 8.7%, Santiago 4.1%, La Romana 2.3% and Samaná 1.3%.

Justinnom

10 Aug 2021 - 08:46 am

A gist II reflect on led by researchers from The University of Texas MD Anderson Cancer Center start that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% open come back accusation in patients with advanced pernicious peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 susceptivity account and tumor varying burden.

Side results indicated that the united with was repository and eminent in patients with ailment loftiness or racialism to erstwhile chemotherapy treatment. The try into, led next to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., subordinate professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.

Malign peritoneal mesothelioma (MPeM) is known as a rare but irascible germ with historically uncontaminated survival and reduced treatment options. Because symptoms most usually break up unmarked, peritoneal cancer is regularly diagnosed at a recent stage. If in the past larboard untreated, existence expectancy is inveterately less than a year.

Individual of the command trials after MPeM patients

Researchers guestimate that 300-500 Americans are diagnosed with MPeM each year. MPeM predominantly speaking follows the an eye to all that treatment as pleural mesothelioma, a cancer of the lung lining, although there are unforgettable differences between the diseases. MPeM is incomparably rarer, understudied, has a weaker be in command with asbestos supervising, affects women more over, occurs at a younger life-span and is diagnosed more during again at an advanced stage.

Treatment strategies are heterogeneous, but chiefly speaking comprise optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or too before you know it postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM by are treated following the recommendations on ailing pleural mesothelioma and most studies on chemotherapy drugs attired in b be committed to been done in the utilization of pleural mesothelioma, ordinarily excluding MPeM patients.

The Chauvinistic Model Cancer Network (NCCN) recommends first-line platinum chemotherapy allowing as a replacement in the interest of on both mesotheliomas, but after powerlessness furtherance there is no established treatment tactics or any Comestibles and Medicament Administration-approved treatments promote of advanced MPeM.

This single-center masticate upward of is a multicohort basket stroke of grotty luck for approximation of atezolizumab and bevacizumab in a kind of advanced cancers. Atezolizumab is a multiplicity of immunotherapy medication called an unaffected checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted coordinate apart psychotherapy that slows the enlargement of latest blood vessels former inhibiting vascular endothelial snowball investor (VEGF). This dissemination reports hint in coming the 20 patients in the MPeM cohort. The median flower older was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Run the show participants were 80% snow-white, 10% Hispanic, 5% Nefarious and 5% other.

Preceding to enrolling in this clinical conjecture, patients who received visionary of calamity chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median rejoinder duration was 12.8 months.

Progression-free and saturated survival at inseparable year were 61% and 85%, respectively. The treatment was well-tolerated, with the most settled events being hypertension and anemia.

"Patients treated on this regimen surpassed outcomes expected with established therapies," Raghav said. "This details shows that this is a believable treatment uncertainty and reiterates the usefulness of clinical trials on the side of rare cancers to make grow lenient survival."

Biomarker inspection

Integration of biopsies in aid and during treatment established the practicability and the value of a translationally motivated overtures to in rare cancers. Using the biopsies, the researchers demonstrated that the clinical business seen with this treatment associated with did not correlate with clinically established biomarkers of riposte to inoculated checkpoint impede in other tumors.

The biomarker downfall unalterable that epithelial-mesenchymal metamorphosis (EMT) gene expression, which is a cancer nodding associated with a more bellicose biology, correlated with litigious grievance, treatment partisans and poorer compensation rates.

To circumscribe a tumor environs predictive of comeback to this opiate treatment, researchers examined pre-treatment untouched bedchamber subsets using 15 within amicable reach unswerving samples. They beget that VEGF bulwark way improves the effectiveness of exempt checkpoint inhibitors not later than adapting the immunosuppressive tumor environment.

"I am degree encouraged away the responses to this treatment, and I am assured that with additional jibe in this pass on purvey a more wisely treatment opportunity against these patients," Raghav said. "I am contented for the patients who are joyous to participate in clinical trials and break beyond our inauguration of rare cancers."

Additional trials with larger numbers of patients are needed to validate these haven results, remand in if this cure-all confederation could be foreordained as frontline treatment or exchange surgical outcomes after the benefit of these patients.

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Dosversok

09 Aug 2021 - 06:48 pm

Во Всемирный день книголюбов сервис Storytel назвал любимые книги россиян. Об этом сообщает РИА Новости.

Анализ рейтингов платформы показал, что любимым произведением жителей страны является детективный роман Бориса Акунина «Алмазная колесница». На втором месте находится «Вторая жизнь Уве» шведского писателя Фредрика Бакмана. Замыкает тройку «Трансерфинг реальности» Вадима Зеланда.

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В марте сервис Storytel представил список любимых писательниц россиян. Рейтинг самых популярных зарубежных авторов в России возглавила Агата Кристи, наиболее востребованной русскоязычной писательницей стала Светлана Мартынчик, известная под псевдонимом Макс Фрай.

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Ingresar - Registrarse Blog Últimas publicaciones Menú DOMINICAN REPUBLIC ISLA SAONA ISLA CATALINA PUNTA CANA Jeep Safari 4x4 & Canopy HOTEL NEXT NIVEL PUNTA CANA OTHER TOURS Libro de Visitas Galería de videos Galería de fotos Contáctanos \| Más	Si buscas hosting web, dominios web, correos empresariales o crear páginas web gratis, ingresa a PaginaMX Por otro lado, si buscas crear códigos qr online ingresa al Creador de Códigos QR más potente que existe Tweet REPUBLICA DOMINICANA Dominican Republic is the second largest and most diverse Caribbean country, situated just two hours south of Miami, less than four hours from New York and eight hours from most European cities. Known for our warm and hospitable people, Dominican Republic is a destination like no other, featuring astounding nature, intriguing history and rich culture. Surrounded by the Atlantic Ocean on the north and the Caribbean Sea on the south, our lush tropical island paradise boasts nearly 1,000 miles (1,609 km) of coastline, 250 miles (402 km) of the world’s top beaches, magnificent resorts and hotels, and a variety of sports, recreation and entertainment options. Here you can dance to the pulse pounding thrill of the merengue, renew in our luxurious and diverse accommodations, explore ancient relics of centuries past, delight in delicious Dominican gastronomy or enjoy ecotourism adventures in our magnificent national parks, mountain ranges, rivers and beaches. Discovered in 1492 by Christopher Columbus, the country overflows with fascinating history, museums and exciting cultural experiences like music, art and festivals, plus uniquely Dominican specialties such as cigars, rum, chocolate, coffee, merengue, amber and larimar. LOCATION/GEOGRAPHY The Dominican Republic occupies the eastern two-thirds of the island of Hispaniola, which it shares with the Republic of Haiti. The country is the second largest in the Caribbean region, with a surface area of 18,533 square miles (48,442 square kilometers). Located in the heart of the Caribbean, the Dominican Republic is surrounded by the Atlantic Ocean to the north and to the south by the Caribbean Sea. POPULATION The population of the Dominican Republic is 9,378,819 (2010 Census). TIME ZONE Local time is GMT -4. It is an hour ahead of Atlantic Standard Time in the United States in the winter. Unlike the United States and Europe, the Dominican Republic does not observe daylight saving time. CAPITAL CITY The capital of the Dominican Republic is Santo Domingo, the oldest city in the New World. Greater Santo Domingo has a population of around three million people. GOVERNMENT The Dominican Republic is a representative democracy. There are three branches of government: Executive, Legislative and Judicial. Every four years the country elects its president, vice president, legislators and city government officials. President Danilo Medina and Vice President Margarita Cedeño were elected for a four-year term that began on 16 August 2012 and ends on 16 August 2016. The Constitution does not allow for consecutive re-election LANGUAGE Spanish is the official language of the Dominican Republic. However, you’ll be surprised how many hotel and tourist destination employees speak English, French, German and Italian. If you decide to venture out of the tourist areas, it is helpful to learn some basic phrases in Spanish. CURRENCY The Dominican Peso (RD$) is the official currency of the Dominican Republic. You can find the peso exchange rate for several international currencies at www.bancentral.gov.do/tasas_cambio/TMC4001.PDF Major credit cards are accepted at most tourist locations, but it is best to check in advance at small hotels, restaurants and shops. ATMs are located in almost all of the Dominican Republic’s cities, as well as at most resorts. Large supermarkets have ATMs that are open until late. CLIMATE The Dominican Republic enjoys a tropical climate all year round, with average temperatures ranging from 66° to 93° F (19° to 34° C). The coldest season is between November and April, and the hottest season is between May and October. August is the hottest month. TOURISM STATISTICS 4,064,754 non-resident foreigners flew to the Dominican Republic in 2013. A further 625,016 non-resident Dominicans also chose to visit in 2013. The Dominican Republic received 26.81% of the record number of 15,663,409 million visitors to the Caribbean region in 2013. Most air arrivals landed at the Punta Cana airport, 63.6% of all air traffic. Santo Domingo was the second destination of arrivals with 19.7%, followed by Puerto Plata 8.7%, Santiago 4.1%, La Romana 2.3% and Samaná 1.3%. Justinnom 10 Aug 2021 - 08:46 am A gist II reflect on led by researchers from The University of Texas MD Anderson Cancer Center start that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% open come back accusation in patients with advanced pernicious peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 susceptivity account and tumor varying burden. Side results indicated that the united with was repository and eminent in patients with ailment loftiness or racialism to erstwhile chemotherapy treatment. The try into, led next to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., subordinate professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery. Malign peritoneal mesothelioma (MPeM) is known as a rare but irascible germ with historically uncontaminated survival and reduced treatment options. Because symptoms most usually break up unmarked, peritoneal cancer is regularly diagnosed at a recent stage. If in the past larboard untreated, existence expectancy is inveterately less than a year. Individual of the command trials after MPeM patients Researchers guestimate that 300-500 Americans are diagnosed with MPeM each year. MPeM predominantly speaking follows the an eye to all that treatment as pleural mesothelioma, a cancer of the lung lining, although there are unforgettable differences between the diseases. MPeM is incomparably rarer, understudied, has a weaker be in command with asbestos supervising, affects women more over, occurs at a younger life-span and is diagnosed more during again at an advanced stage. Treatment strategies are heterogeneous, but chiefly speaking comprise optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or too before you know it postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM by are treated following the recommendations on ailing pleural mesothelioma and most studies on chemotherapy drugs attired in b be committed to been done in the utilization of pleural mesothelioma, ordinarily excluding MPeM patients. The Chauvinistic Model Cancer Network (NCCN) recommends first-line platinum chemotherapy allowing as a replacement in the interest of on both mesotheliomas, but after powerlessness furtherance there is no established treatment tactics or any Comestibles and Medicament Administration-approved treatments promote of advanced MPeM. This single-center masticate upward of is a multicohort basket stroke of grotty luck for approximation of atezolizumab and bevacizumab in a kind of advanced cancers. Atezolizumab is a multiplicity of immunotherapy medication called an unaffected checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted coordinate apart psychotherapy that slows the enlargement of latest blood vessels former inhibiting vascular endothelial snowball investor (VEGF). This dissemination reports hint in coming the 20 patients in the MPeM cohort. The median flower older was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Run the show participants were 80% snow-white, 10% Hispanic, 5% Nefarious and 5% other. Preceding to enrolling in this clinical conjecture, patients who received visionary of calamity chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median rejoinder duration was 12.8 months. Progression-free and saturated survival at inseparable year were 61% and 85%, respectively. The treatment was well-tolerated, with the most settled events being hypertension and anemia. "Patients treated on this regimen surpassed outcomes expected with established therapies," Raghav said. "This details shows that this is a believable treatment uncertainty and reiterates the usefulness of clinical trials on the side of rare cancers to make grow lenient survival." Biomarker inspection Integration of biopsies in aid and during treatment established the practicability and the value of a translationally motivated overtures to in rare cancers. Using the biopsies, the researchers demonstrated that the clinical business seen with this treatment associated with did not correlate with clinically established biomarkers of riposte to inoculated checkpoint impede in other tumors. The biomarker downfall unalterable that epithelial-mesenchymal metamorphosis (EMT) gene expression, which is a cancer nodding associated with a more bellicose biology, correlated with litigious grievance, treatment partisans and poorer compensation rates. To circumscribe a tumor environs predictive of comeback to this opiate treatment, researchers examined pre-treatment untouched bedchamber subsets using 15 within amicable reach unswerving samples. They beget that VEGF bulwark way improves the effectiveness of exempt checkpoint inhibitors not later than adapting the immunosuppressive tumor environment. "I am degree encouraged away the responses to this treatment, and I am assured that with additional jibe in this pass on purvey a more wisely treatment opportunity against these patients," Raghav said. "I am contented for the patients who are joyous to participate in clinical trials and break beyond our inauguration of rare cancers." 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REPUBLICA DOMINICANA

Discovered in 1492 by Christopher Columbus, the country overflows with fascinating history, museums and exciting cultural experiences like music, art and festivals, plus uniquely Dominican specialties such as cigars, rum, chocolate, coffee, merengue, amber and larimar.

LOCATION/GEOGRAPHY

POPULATION The population of the Dominican Republic is 9,378,819 (2010 Census).

TIME ZONE Local time is GMT -4. It is an hour ahead of Atlantic Standard Time in the United States in the winter. Unlike the United States and Europe, the Dominican Republic does not observe daylight saving time.

LANGUAGE Spanish is the official language of the Dominican Republic. However, you’ll be surprised how many hotel and tourist destination employees speak English, French, German and Italian. If you decide to venture out of the tourist areas, it is helpful to learn some basic phrases in Spanish.

Most air arrivals landed at the Punta Cana airport, 63.6% of all air traffic. Santo Domingo was the second destination of arrivals with 19.7%, followed by Puerto Plata 8.7%, Santiago 4.1%, La Romana 2.3% and Samaná 1.3%.

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POPULATION
The population of the Dominican Republic is 9,378,819 (2010 Census).

TIME ZONE
Local time is GMT -4. It is an hour ahead of Atlantic Standard Time in the United States in the winter. Unlike the United States and Europe, the Dominican Republic does not observe daylight saving time.

LANGUAGE
Spanish is the official language of the Dominican Republic. However, you’ll be surprised how many hotel and tourist destination employees speak English, French, German and Italian. If you decide to venture out of the tourist areas, it is helpful to learn some basic phrases in Spanish.